Cancer Pathway

Kidney Cancer: your pathway, step by step

Kidney cancer is now often found by chance, on a scan done for another reason, while it is still small. Many tumours can be treated with the kidney kept. This guide explains the steps, one stage at a time.

Written for patients and reviewed by Dr. Anshuman Singh, Uro-Oncologist, on 7 October 2026.

Start here

What is kidney cancer?

The kidneys filter the blood and make urine. The most common kidney cancer, renal cell carcinoma, starts in the kidney tissue itself. A different kind starts in the lining of the kidney’s drainage channel; it is covered in the Upper Tract guide.

Not every kidney lump is cancer, and not every cancer needs the same treatment. The tests below decide how likely the lump is to be cancer, how far it has gone, and how well the other kidney is working.

How kidney cancer is usually found

  • By chance on an ultrasound or CT scan done for another reason. This is now the most common way.
  • Blood in the urine, a lump or ache in the side, or a pain that does not go away.
  • Less often: unexplained weight loss, fever, tiredness or high blood pressure.
  • Many kidney cancers cause no symptoms at all while they are small.

Step 1

The tests that decide the plan

Treatment is chosen only after these results are put together.

CT or MRI scan with contrast
Shows the size and nature of the tumour, whether it has entered the kidney vein, and whether lymph nodes or other organs are involved.
Kidney function and blood tests
Creatinine (eGFR), haemoglobin and calcium. They show how well both kidneys work, which matters a great deal in choosing the operation.
Chest scan
A CT of the chest checks the lungs, the most common place for the cancer to spread.
Biopsy (only in some cases)
Used when the diagnosis is unclear, before treatments that do not remove the tumour (such as ablation), or before medicines for cancer that has spread. It is not needed before most operations.

Step 2

Find what applies to you

Choose your stage and a few details. The page then shows what it means, the options, what to take into account and what to ask, with a checklist you can download.

Living with treatment

Side effects and recovery

These depend on the treatment chosen. Most can be reduced or managed, so ask about them before you decide.

Lower kidney function
Any kidney operation reduces function a little. Keeping the kidney, controlling blood pressure and diabetes, drinking enough fluid and avoiding unnecessary painkillers protect what is left.
Wound pain, hernia or bleeding
Usual after any operation. Keyhole operations cause smaller wounds and a faster recovery.
Tiredness, diarrhoea, rash, mouth sores, high blood pressure
Common with targeted tablets and immunotherapy. Most can be controlled when reported early.
Immune side effects
Immunotherapy can inflame the thyroid, lungs, bowel or liver. They are treatable but need prompt attention.

After treatment

Follow-up

  • Scans (usually CT of the chest and abdomen) and blood tests at set intervals, often every six months in the first years, then yearly. The schedule depends on your risk after surgery.
  • Kidney function and blood pressure are checked regularly.
  • Kidney cancers can return after many years, so follow-up continues for a long time.

When to get help quickly

  • Heavy bleeding in the urine, or passing clots.
  • Fever, or a wound that is red, swollen or leaking.
  • New breathlessness, chest pain or swelling of one leg.
  • On immunotherapy: severe diarrhoea, new cough or breathlessness, rash, or severe tiredness.

Common questions

Questions patients ask

Can I live normally with one kidney?

Yes. One healthy kidney is enough for normal life for most people. It is important to protect it by controlling blood pressure and diabetes and avoiding unnecessary painkillers.

Is a kidney lump always cancer?

No. Some lumps are harmless cysts or non-cancerous tumours. A scan, and sometimes a biopsy, helps to tell them apart.

Do I need chemotherapy?

Not usually. Kidney cancer responds poorly to traditional chemotherapy. When it has spread, immunotherapy and targeted tablets are used instead.

Can small tumours just be watched?

Some small tumours grow slowly and can be watched with regular scans, mainly in older patients or those with other illnesses. This is decided case by case.

What is the chance the cancer will come back?

It depends on the stage and the findings in the removed tumour. Scoring systems use the final report to estimate it and to plan how closely you are followed.

Want to talk through your own reports?

This guide is general information and does not replace a medical opinion. An unhurried one-to-one discussion with Dr. Anshuman Singh, with your family welcome, so that you understand every option before you decide. Bring your reports and scans to a consultation with Dr. Anshuman Singh, in the clinic or by teleconsultation.